Relative importance of STAT4 in murine tuberculosis

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Relative importance of STAT4 in murine tuberculosis.

This study was designed to determine the roles of STAT proteins in defence against mycobacterial infection. Airborne infection of STAT4 knockout (KO) mice with a Mycobacterium tuberculosis strain induced large granulomas with massive neutrophil infiltration over time, while that in STAT6 KO mice did not. The STAT4 KO mice succumbed to mycobacterial infection by the 80th day after infection. Com...

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ژورنال

عنوان ژورنال: Journal of Medical Microbiology

سال: 2003

ISSN: 0022-2615,1473-5644

DOI: 10.1099/jmm.0.05026-0